Electro Plating, High-Purity Solvents

Propargyl Chloride

Propargyl chloride, scientifically identified as 3-chloro-1-propyne with the CAS registry number 624-65-7, represents a highly versatile and reactive organochlorine compound widely utilized within the global chemical manufacturing industry. This colorless to pale yellow liquid is characterized by its distinctive pungent odor and possesses a dual functional nature, featuring both a terminal alkyne group and a primary alkyl halide moiety. Such structural attributes facilitate a broad spectrum of chemical transformations, including nucleophilic substitutions, coupling reactions, and cyclizations. As a fundamental building block, it serves a critical role in the synthesis of diverse pharmaceuticals, agrochemicals, and specialized organic intermediates. Due to its high reactivity and flammable nature, propargyl chloride requires stringent handling protocols, specialized storage conditions, and rigorous safety measures to mitigate risks associated with its volatility and potential toxicity. Its utility as a precursor for propargyl groups makes it indispensable for researchers developing innovative molecular structures across advanced material science

Attributes

Key Features and Benefits

High reactivity due to the presence of alkyne and chlorine.
Versatile building block for the introduction of propargyl functional groups.
Excellent solubility in common organic solvents like ethanol and ethers.
Clear liquid state facilitates precise volumetric measurement and chemical handling.
High purity grades available to meet stringent pharmaceutical manufacturing standards.
Facilitates Sonogashira coupling and click chemistry reactions very efficiently.
Reliable precursor for synthesizing complex heterocyclic compounds and alkynylated derivatives.
Demonstrates consistent performance in diverse and complex nucleophilic substitution pathways.
Proven efficacy in stabilizing specific chemical intermediates during multi-step synthesis.
Globally available with comprehensive technical documentation and safety data sheets.

Specifications

Technical Highlights

Molecular Formula: C3H3Cl with a molecular weight of 74.51 g/mol.
Boiling point approximately 57 degrees Celsius at standard atmospheric pressure.
Density of 1.03 g/mL ensures predictable behavior in aqueous mixtures.
Flash point typically around 18 degrees Celsius indicating high flammability.
Refractive index of 1.432 contributes to quality control via verification.
Reacts readily with magnesium to form propargyl Grignard reagents synthesis.
Stabilized often with small amounts of epichlorohydrin or magnesium carbonate.
Vapor pressure necessitates storage in cool, well-ventilated, explosion-proof environments.
Chemically incompatible with strong oxidizing agents and strong chemical bases.
CAS number 624-65-7 ensures unambiguous identification within global databases.

Download Technical Data Sheet (TDS)

Practical industry uses

Applications

Primary intermediate in the synthesis of agricultural fungicides and herbicides.
Essential reagent for producing pharmaceutical drugs including antihypertensives and anti-cancer.
Used in the manufacturing of soil fumigants for crop protection.
Crucial component in the formulation of corrosion inhibitors for acidizing.
Utilized in the production of specialized polymers and advanced coatings.
Serves as a key precursor for flavoring agents and fragrances.
Employed in laboratory research for terminal alkyne modification and functionalization.
Integral to the synthesis of propargyl alcohols and diverse propargylamines.
Applied in the development of sophisticated and efficient electroplating additives.
Widely utilized in specialized fine chemical processing and metallurgical environments.